ご紹介いただく先生方・医療関係者の方
スタッフ紹介
呼吸器外科の診療
呼吸器センター診療案内
呼吸器外科の基礎研究
連絡先／お問い合わせ

TOP > 医療関係者の方 > 呼吸器外科の基礎研究 > 実績　2009年以前

　 実績 2009年以前

2009年

  • Maeda J, Inoue M, Nakabayashi K, Otomo Y, Shintani Y, Ohta M, Okumura M, Matsuura N. Rapid diagnosis of lymph node metastasis in lung cancer with loop-mediated isothermal amplification assay using carcinoembryonic antigen-mRNA. Lung Cancer 2009;65:324-327.
  • Oda T, Tian T, Inoue M, Ikeda JI, Qiu Y, Okumura M, Aozasa K, Morii E. Tumorigenic Role of Orphan Nuclear Receptor NR0B1 in Lung Adenocarcinoma. Am J Pathol 2009;175:1235-1245.
  • Oda T, Morii E, Inoue M, Ikeda J, Aozasa K, Okumura M. Prognostic significance of heat shock protein 105 in lung adenocarcinoma. Molecular Med Rep 2009;2:603-607.
  • Ikeda J, Oda T, Inoue M, Uekita T, Sakai R, Okumura M, Aozasa K, Morii E. Expression of CUB domain containing protein (CDCP1) is correlated with prognosis and survival of patients with adenocarcinoma of lung. Cancer Sci. 2009;100:429-433.
  • Tokunaga T, Hayashi A, Kadota Y, Shiono H, Inoue M, Sawabata N, Okumura M. Regulation of Th-POK and Runx3 in T cell development in human thymoma. Autoimmunity 2009;42:653-660.
  • Shiono H, Okumura M, Yasumoto K. National survey of endoscopic thymectomy : survey report from the Japanese Association for research on tye thymus. General Thoracic Cardiovasc Surg 2009;57:22-27.
  • Utsumi T, Shiono H, Kadota Y, Matsumura A, Maeda H, Ohta M, Yoshioka Y, Koizimi M, Inoue T, Okumura M. Postoperative radiation therapy after complete resection of thymoma has little impact on survival. Cancer 2009;115:5413-5420.
  • Shigemura N, Bermudez C, Hattler BG, Johnson B, Crespo M, Pilewski J, Toyoda Y. Impact of graft volume reduction for oversized grafts after lung transplantation on outcome in recipients with end-stage restrictive pulmonary diseases. J Heart Lung Transplant. 2009;28:130-134.

このページ上部へもどる

2008年

  • Inoue M, Maeda J, Ohta M, Sawabata N, Matsuura N, Okumura M. Detection of occult lymph node metastasis in lung cancer patients using molecular technique: A review. Research Media 2008;141-149.
  • Inoue M, Takakuwa T, Minami M, Shiono H, Utsumi T, Kadota Y, Nasu T, Aozasa K, Okumura M. Clinicopathologic factors influencing postoperative prognosis in patients with small-sized adenocarcinoma of the lung. J Thorac Cardiovasc Surg 2008;135:830-836.
  • Utsumi T, Shiono Y, Matsumura A, Maeda H, Ohta M, Tada H, Akashi A, Okumura M. Stage III thymoma: Relationship of local invasion to recurrence. J Thorac Cardiovasc Surg 2008;136:1481-1485.
  • Willcox N, Leite MI, Kadota Y, Jones M, Meager A, Subrahmanyam P, Dasgupta B, Morgan BP, Vincent A. Autoimmunizing mechanisms in thymoma and thymus. Ann N Y Acad Sci. 2008;1132:163-173.
  • Okumura M, Fujii Y, Shiono H, Inoue M, Minami M, Utsumi T, Kadota Y, Sawa Y. Immunological function of thymoma and pathogenesis of paraneoplastic myasthenia gravis. Gen Thorac Cardiovasc Surg.2008;56:143-15
  • Okumura M, Shiono H, Minami M, Inoue M, Utsumi T, Kadota Y, Sawa Y. Clinical and pathological aspects of thymic epithelial tumors. Gen Thorac Cardiovasc Surg 2008;56:10-16.
  • Hill ME, Shiono H, Newsom-Davis J, Willcox N. The myasthenia gravis thymus: a rare source of human autoantibody-secreting plasma cells for testing potential therapeutics. J Neuroimmunol. 2008;201-202:50-56.

このページ上部へもどる

2007年

  • Shiono H, Okumura M, Sawabata N, Utsumi T, Inoue M, Minami M, Tomiyama N, Matsuda H, Sawa Y. Virtual mediastinoscopy for safer and more accurate mediastinal exploration. Ann Thorac Surg 2007;84:995-999.
  • Shigemura N, Yim AP. Variation in the approach to VATS lobectomy:Effect on the evaluation of surgical morbidity following VATS lobectomy for the treatment of stage IA non-small cell lung cancer. Thorac Surg Clin 2007;17:233-239.
  • Okumura M, Goto M, Ideguchi K, Tamura M, Sasaki H, Tanaka H, Matsumura A, Iuchi K. Factors associated with outcome of segmentectomy for non-small cell lung cancer: Long term follow-up study at a single institution in Japan. Lung Cancer 2007;58:231-237.
  • Inoue M, Okumura M, Minami M, Shiono H, Sawabata N, Utsumi T, Ohno Y, Sawa Y. Cardiopulmonary co-morbidity: a critical negative prognostic predictor for pulmonary resection following preoperative chemotherapy and/or radiation therapy in lung cancer patients. Gen Thorac Cardiovasc Surg 2007;55:315-321.
  • Sawabata N, Okumura M, Utsumi T, Inoue M, Shiono H, Minami M, Sawa Y. Circulating tumor cells in peripheral blood caused by surgical manipulation of non-small cell lung cancer: pilot study using an immunocytology method. Gen Thorac Cardivasc Surg 2007; 55: 189-192.
  • Sawabata N, Miyoshi S, Matsumura A, Ohta M, Maeda H, Sueki H, Hayakawa M, Okumura M, Sawa Y. Prognosis of smokers following resection of pathological stage I non-small-cell lung carcinoma. Gen Thorac Cardiovasc Surg. 2007;55:420-424
  • Hayashi A, Shiono H. Ohta M. Ohta K. Okumura M. Sawa Y. Heterogeneity of immunological features of AChR/MuSK autoantibody-negative myasthenia gravis. J Neuroimmunol 2007;179:163-168.
  • Okumrua, M, Shiono H, Inoue M, Tanaka H, Yoon HE, Nakagawa K, Matsumura A, Ohta M, Iuchi K, Matsuda H. Outcome of surgical treatment for recurrent thymic epithelial tumors with reference to World Health Organization histologic classification system. J Surg Oncol 2007;95:40-44.
  • Natsag J, Tomiyama N, Inoue A, Mihara N, Johkoh T, Sumikawa H, Honda O, Shiono H, Okumura M, Nakamura H. Preoperative assessment of thymic veins on multidetector row CT: optimization of contrast material volume. Radiat Med. 2007;27:202-210.
  • Inoue M, Minami M, Ichikawa H, Fukushima N, Shiono H, Utsumi T, Okumura M, Sawa Y. Extracorporeal membrane oxygenation with direct central cannulation followed by delayed chest closure for graft dysfunction after lung transplantation: Report of two cases with pulmonary arterial hypertension. J Thorac Cardiavasc Surg 2007;133:1680-1681.

このページ上部へもどる

2006年

  • Shigemura N, Akashi A, Funaki S, Nakagiri T, Inoue M, SawabataN, Shiono H, Minami M, Takeuchi Y, Okumura M, Sawa Y. Long-term outcomes after a variety of video-assisted thoracoscopic lobectomy approaches for clinical stage IA lung cancer: A multi-institutional study. J Thorac Cardiovasc Surg 2006;132:507-512.
  • Inoue M, Minami M, Shiono H, Sawabata N, Ideguchi K, Okumura M. Clinicopathologic study of resected, peripheral, small-sized, non?small cell lung cancer tumors of 2 cm or less in diameter: Pleural invasion and increase of serum carcinoembryonic antigen level as predictors of nodal involvement. J Thorac Cardiovasc Surg 2006;131:988-993.
  • Maeda J, Inoue M. Okumura M. Ohta M. Minami M. Shiono H. Shintani Y. Matsuda H. Matsuura N. Detection of occult tumor cells in lymph nodes from non-small cell lung cancer patients using reverse transcription-polymerase chain reaction for carcinoembryonic antigen mRNA with the evaluation of its sensitivity. Lung Cancer 2006;52:235-240.
  • Shigemura N, Okumura M, Mizuno S, Imanishi Y, Nakamura T, Sawa Y. Autologous transplantation of adipose tissue-derived stromal cells ameliorates pulmonary emphysema. Am J Transplant 2006;6;2592-2600
  • Nakatsuka S, Oji Y, Horiuchi T, Kanda T, Kitagawa M, Takeuchi T, Kawano K, Kuwae Y, Yamauchi A, Okumura M, Kitamura Y, Oka Y, Kawase I, Sugiyama H, Aozasa K. Immunohistochemical detection of WT1 protein in a variety of cancer cells. Modern Pathology 2006;19:804-814.
  • Shigemura N, Shiono H, Inoue M, Minami M, Ohta M, Okumura M, Matsuda H. Inclusion of the transcervical approach in video-assisted thoracoscopic extended thymectomy (VATET) for myasthenia gravis: a prospective trial. Surg Endosc. 2006;20:1614-8.
  • Inoue M, Minami M. Shiono H. Miyoshi S. Takeda S. Ohta M. Goto M. Takano H. Sawa Y. Okumura M. Efficient clinical application of percutaneous cardiopulmonary support for perioperative management of huge anterior mediastinal tumor. J Thorac Cardiovasc Surg 2006;131:755-756.
  • Shiono H, Inoue A, Tomiyama N, Shigemura N, Ideguchi K, Inoue M, Minami M, Okumura M. Safer video-assisted thoracoscopic thymectomy after location of thymic veins with multidetector computed tomography. Surg Endosc. 2006;20:1419-22.
  • Sakamaki Y, Minami M. Ohta M. Takahashi T. Matsumiya G. Miyoshi S. Matsuda H. Pulmonary artery dissection complicating lung Transplantation for primary pulmonary hypertension. Ann Thorac Surg 2006;81:360-362.
  • Shigemura N, Okumura M, Mizuno S, Imanishi Y, Nakamura T, Sawa Y. Autologous transplantation of adipose tissue-derived stromal cells ameliorates pulmonary emphysema. Am J Transplant. 2006;6:2592-2600.
  • Shigemura N, Okumura M, Mizuno S, Imanishi Y, Matsuyama A, Shiono H, Nakamura T, Sawa Y. Lung tissue engineering technique with adipose stromal cells improves surgical outcome for pulmonary emphysema. Am J Respir Crit Care Med. 2006;174:1199-1205.

このページ上部へもどる

2005年

  • Shintani Y, Ohta M, Minami M, Shiono H, Hirabayashi H, Inoue M, Matsumiya G, Matsuda H. Long-term graft patency after replacement of the brachiocephalic veins combined with resection of mediastinal tumors. J Thorac Cardiovasc Surg. 2005;129:809-812
  • Inada K, Okumura M, Shiono H, Inoue M, Kadota Y, Ohta M, Matsuda H. Role of positive selection of thymoma-associated T cells in the pathogenesis of myasthenia gravis. J Surg Res. 2005;126:34-40.
  • Funakoshi Y, Shiono H, Inoue M, Kadota Y, Ohta M, Matsuda H, Okumura M, Eimoto T. Glucocorticoids induce G1 cell cycle arrest in human neoplastic thymic epithelial cells. J Cancer Res Clin Oncol. 2005;131:314-322.
  • Ohmori K, Takeda S, Miyoshi S, Minami M, Nakane S, Ohta M, Sawa Y, Matsuda H. Application of HVJ-liposome mediated gene transfer in lung transplantation-distribution and transfection efficiency in the lung. Eur J Cardiothorac Surg. 2005;27:768-773.
  • Shigemura N, Sawa Y, Mizuno S, Ono M, Ohta M, Nakamura T, Kaneda Y, Matsuda H. Amelioration of pulmonary emphysema by in vivo gene transfection with hepatocyte growth factor in rats. Circulation 2005;111:1407-1414.
  • Shigemura N, Sawa Y, Mizuno S, Ono M, Minami M, Okumura M, Nakamura T, Kaneda Y, Matsuda H. Induction of Compensatory Lung Growth in Pulmonary Emphysema Improves Surgical Outcomes in Rats. Am J Respir Crit Care Med 2005;171:1237-1245.

このページ上部へもどる

2004年

  • Inoue M, Ohta M, Iuchi K, Matsumura A, Ideguchi K, Yasumitsu T, Nakagawa K, Fukuhara K, Maeda H, Takeda S, Minami M, Ohno Y, Matsuda H. Benefits of surgery for patients with pulmonary metastases from colorectal carcinoma. Ann Thorac Surg. 2004;78:238-244.
  • Ohta M, Hirabayashi H. Shiono H. Minami M. Maeda H. Sawabata N. Matsumiya G. Miyoshi S. Matsuda H. Hemi-clamshell approach for advanced primary lung cancer. Thorac Cardiovasc Surgeon 2004;52:200-205.
  • Shintani Y, Higashiyama S. Ohta M. Hirabayashi H. Yamamoto S. Yoshimasu T. Matsuda H. Matsuura N. Overexpression of ADAM9 in non-small cell lung cancer correlates with brain metastasis. Cancer Res 2004;64:4190-4196.
  • Shintani Y, Ohta M. Hirabayashi H. Tanaka H. Iuchi K. Nakagawa K. Maeda H. Kido T. Miyoshi S. Matsuda H. Thymidylate synthase and dihydropyrimidine dehydrogenase mRNA levels in tumor tissues, and the efficacy of 5-fluorouracil in patients with non-small-cell lung cancer. Int J Cancer 2004;45:189-196.
  • Miyoshi S, Iuchi K, Nakamura K, Nakagawa K, Maeda H, Ohno K, Nakahara K, Nakano N, Okumura M, Ohta M. Induction concurrent chemoradiation therapy for invading apical non-small cell lung cancer. Jpn J Thorac Cardiovasc Surg 2004;52:120-126.
  • Chan JKC, Zettl A, Inoue M, de Jong D, Yoneda S. Metaplastic thymoma. P.169-170. In Travis WD, Brambilla E, Mueller-Hermelink HK, Harris CC, eds. WHO classification of tumours. Pathology & Genetics. Tumours of the Lung, Pleura, Thymus, and Heart. IARC press, Lyon, 2004.
  • Takeda S, Sawabata N, Inoue M ,Koma M, Maeda H, Hirano H. Thymic carcinoma. Clinical institutional experience with 15 patients. Eur J Cardio-thorac Surg. 2004;26:401-406.
  • Takeda S, Miyoshi S, Minami M, Matsuda H. Intrathoracic neurogenic tumors--50 years’ experience in a Japanese institution. Eur J Cardiothorac Surg. 2004;26:807-812.
  • Ohmori K, Takeda S, Miyoshi S, Minami M, Nakane S, Ohta M, Sawa Y, Matsuda H. Attenuation of lung injury in allograft rejection using NF-kB decoy transfection-novel strategy for use in lung transplantation. Eur J Cardiothorac Surg 2004;27:23-27.
  • Matsuda H, Minami M. Ichikawa H. Fukushima N. Ohta M. Saito M. Kita T. Matsushita T. Living-related lobar transplantation and simultaneous atrial septal defect closure in a young patient with irreversible pulmonary hypertension : a case report. Heart Vessel 2004;19:203-207.

このページ上部へもどる

2003年

  • Okumura M, Ohta M, Takeuchi Y, Shiono H, Inoue M, Fukuhara K, Kadota Y, Miyoshi S, Fujii Y, Matsuda H. The immunologic role of thymectomy in the treatment of myasthenia gravis: implication of thymus-associated B-lymphocyte subset in reduction of the anti-acetylcholine receptor antibody titer. J Thorac Cardiovasc Surg. 2003;126(6):1922-1928.
  • Ohta M, Hirabayashi H, Okumura M, Minami M, Matsuda H. Thoracoscopic thymectomy using anterior chest wall lifting method. Ann Thorac Surg 2003;76:1310-1311.
  • Shiono H, Roxanis I, Zhang W, Sims GP, Meager A, Jacobson LW, Liu JL, Matthews I, Wong YL, Bonifati M, Micklem K, Stott DI, Todd JA, Beeson D, Vincent A, Willcox N. Scenarios for autoimmunization of T and B cells in myasthenia gravis. Ann N Y Acad Sci. 2003; 998:237-256.
  • Shiono H, Wong YL. Matthews I. Liu J-L. Zhang W. Sims G. Meager A. Beesen D. Vincent A. Willcox N. Spontaneous production of anti-IFN-a and anti-IL-12 autoantibodies by thymoma cells from myasthenia gravis patients suggests autoimmunization in the tumor. Int Immunol 2003;15:903-913.
  • Inoue M, Starostik P, Zettl A, Stroebel P, Schwarz S, Scaravilli F, Henry K, Willcox N, Mueller-Hermelink HK, Marx A. Correlating genetic aberrations with world health organization-defined histology and stage across the spectrum of thymoma. Cancer Res 2003;63:3708-3715.
  • Hazama K, Miyagawa S, Miyazawa T, Yamada J, Tomonaga K, Ota M, Matsuda H, Shirakura R. The significance of N-linked glycosylation in pig endogenous retrovirus infectivity. Biochem Biophys Res Commun 2003;310:327-333.

このページ上部へもどる

2002年

  • Okumura M, Ohta M. Tateyama H. Nakagawa K. Matsumura A. Maeda H. Tada H. Eimoto T. Matsuda H. Masaoka A. The World Health Organization histologic classification system reflects the oncologic behavior of thymoma. A clinical study of 273 patients. Cancer 2002;94:624-632
  • Inoue M, Marx A, Zettl A, Stroebel P, Mueller-Hermelink HK, Starostik P. Chromosome 6 suffers frequent and multiple aberrations in thymoma. Am J Pathol 2002;161:1507-1
  • Fukuhara K, Okumura M, Shiono H, Inoue M, Kadota Y, Miyoshi S, Matsuda H. A study on CD45 isoform expression during T-cell development and selection events in the human thymus. Hum Immunol 2002;63:394-404.
  • Hirabayashi H, Ohta M, Okumura M, Matsuda H. Appearance of thymoma 15 years after extended thymectomy for myasthenia gravis without thymoma. Eur J Cardiothorac Surg 2002;22:479-481
  • Sakamaki Y, Matsumoto K, Mizuno S, Miyoshi S, Matsuda H, Nakamura T. Hepatocyte growth factor stimulates proliferation of respiratory epithelial cells during postpneumonectomy compensatory lung growth in mice. Am J Respir Cell Mol Biol 2002;26:525-533.

このページ上部へもどる

2001年

  • Tateyama H, Saito Y, Fujii Y, Okumura M, Nakamura K, Tada H, Yasumitsu T, Eimoto T. The spectrum of micronodular thymic epithelial tumors with lymphoid B-cell hyperplasia. Histopathol 2001;38:519-527.
  • Tomiyama N, Muller NL, Ellis SJ, Cleverley JR, Okumura M, Miyoshi S, Kusumoto M, Johkoh T, Yoshida S, Mihara N, Honda O, Kozuka T, Hamada S, Nakamura H. Invasive and noninvasive thymoma: distinctive CT features. J Comput Assist Tomograp 2001;25: 388-393.
  • Okumura M, Miyoshi S, Fujii Y, Takeuchi Y, Shiono H, Inoue M, Fukuhara K, Kadota Y, Tateyama H, Eimoto T, Matsuda H. Clinical and functional significance of WHO classification on human thymic epithelial neoplasm. Am J Surg Pathol 2001;25:103-110.
  • Miyoshi S, Minami M, Ohta M, Okumura M, Takeda S, Matsuda H. Single lung transplantation from a brain-dead donor for a patient with idiopathic pulmonary fibrosis: A breakthrough after new legislation in Japan. Jpn J Thorac Cardiovasc Surg 2001;49:398-403.

このページ上部へもどる

2000年

  • Kadota Y, Okumura M, Miyoshi S, Kitagawa-Sakakida S, Inoue M, Shiono H, Maeda Y, Kinoshita T, Shirakura R, Matsuda H. Altered T cell development in human thymoma is related to impairment of MHC class II transactivator expression induced by interferon-gamma (IFN-gamma). Clin Exp Immunol 2000;121:59-68
  • Koma M, Miyagawa S, Honke K, Ikeda Y, Koyota S, Miyoshi S, Matsuda H, Tsuji S, Shirakura R, Taniguchi N. Reduction of the major xenoantigen on glycosphingolipids of swine endothelial cells by various glycosyltransferases. Glycobiol 2000;10:745-751.

このページ上部へもどる

1999年

  • Utsumi T, Mizuta T, Fujii Y, Shiono H, Okumura M, Minami M, Takeda S, Miyoshi S, Matsuda H. Nitric oxide production by bronchoalveolar cells during allograft rejection in the rat. Transplantation. 1999;67:1622-1626.
  • Miyoshi S, Demertzis S, Eckstein F, Hohlfeld J, Schaefers HJ. Chest size matching in single and double lung transplantation. Jpn J Thorac Cardiovasc Surg. 1999;47:163-170.

このページ上部へもどる

1998年

  • Kishima H, Takeda S, Miyoshi S, Matsumura A, Minami M, Utsumi T, Omori K, Nakahara K, Matsuda H. Microvascular permeability of the non-heart-beating rabbit lung after warm ischemia and reperfusion: role of neutrophil elastase. Ann Thorac Surg. 1998;65:913-918.

このページ上部へもどる

1997年

  • Mizuta T, Fujii Y, Minami M, Tanaka S, Utsumi T, Kosaka H, Shirakura R, Matsuda H. Increased nitric oxide levels in exhaled air of rat lung allografts. J Thorac Cardiovasc Surg. 1997;113:830-835.
  • Takeda S, Sawa Y, Minami M, Kaneda Y, Fujii Y, Shirakura R, Yanagisawa M, Matsuda H. Experimental bronchiolitis obliterans induced by in vivo HVJ-liposome-mediated endothelin-1 gene transfer. Ann Thorac Surg. 1997;63:1562-1567.

このページ上部へもどる

1996年

  • Yoon HE, Mizuta T, Minami M, Fujii Y, Matsumura A, Nakahara K, Matsuda H. Exercise performance of rats after isogenic left or right lung transplantation followed by contralateral pulmonary artery ligation. J Heart Lung Transplant. 1996;15:605-611.

このページ上部へもどる

1995年

  • Minami M, Nakahara K, Matsumura A, Mizuta T, Yoon HE, Sakaguchi M, Mochizuki T, Yamatodani A, Matsuda H. Histamine release from pulmonary mast cells after lung transplantation in rats. J Heart Lung Transplant. 1995;14:505-511

このページ上部へもどる

1990年

  • Miyoshi S, Schaefers HJ, Trulock EP, Yamazaki F, Schreinemakers H, Patterson GA, Cooper J. Donor selection for single and double lung transplantation. Chest size matching and other factors influencing posttransplantation vital capacity. Chest. 1990;98:308-313.
  • Miyoshi S, Trulock EP, Schaefers HJ, Hsieh CM, Patterson GA, Cooper JD. Cardiopulmonary exercise testing after single and double lung transplantation. Chest. 1990;97:1130-1136.

このページ上部へもどる

1989年

  • Mizuta T, Kawaguchi A, Nakahara K, Kawashima Y. Simplified rat lung transplantation using a cuff technique. J Thorac Cardiovasc Surg. 1989;97:578-581.

このページ上部へもどる